Ryan Selkis, the founder of the cryptocurrency research company Messari, has given advice regarding the sale of bitcoins. He recommends that investors hold onto their bitcoins in the coming months as if their lives depend on it, and then lock in some profits when the MVRV (Market Value to Realized Value) ratio reaches 2-3. Selkis advises setting aside half of the proceeds for tax payments and using the remaining part for further investments.

MVRV is an indicator that shows the ratio of Bitcoin's market value to its realized value. On December 5, this indicator exceeded the value of 2, with the Bitcoin price fluctuating around $44,000. Historical data shows that the optimal time to sell occurs when MVRV reaches at least 2.6, and to buy when it drops below 1.

This advice is based on the analysis of market trends and can be useful for investors looking to maximize their profits and minimize risks when trading Bitcoin.